Positionally modified siRNA constructs

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United States of America Patent

PATENT NO 8394947
APP PUB NO 20080146788A1
SERIAL NO

11569939

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Abstract

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The present invention provides oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one embodiment the oligomeric compounds comprise double stranded constructs wherein one of the strands capable of hybridizing to a nucleic acid target, and has a plurality of modified ribofuranosyl nucleosides at defined locations. The presence of modifications at such defined positions greatly enhances the properties of the corresponding compositions.

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Patent Owner(s)

  • IONIS PHARMACEUTICALS, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allerson, Charles San Diego, US 49 2504
Bhat, Balkrishen Carlsbad, US 172 7018
Dande, Prasad Cambridge, US 29 678
Griffey, Richard H Vista, US 162 5636
Prakash, Thazha P Carlsbad, US 179 4898
Swayze, Eric E Carlsbad, US 344 9248

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