Solid pharmaceutical dosage form
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United States of America Patent
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Mar 19, 2013
Grant Date -
Jan 26, 2012
app pub date -
Sep 22, 2011
filing date -
Aug 28, 2003
priority date (Note) -
In Force
status (Latency Note)
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Abstract
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
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