Chemical linkers and conjugates thereof
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United States of America Patent
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Mar 19, 2013
Grant Date -
Apr 15, 2010
app pub date -
Nov 2, 2009
filing date -
May 19, 2004
priority date (Note) -
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Abstract
The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine, or disulfide linker. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
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