Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides

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United States of America Patent

PATENT NO 8399614
APP PUB NO 20080187491A1
SERIAL NO

11925735

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Abstract

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Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

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Patent Owner(s)

Patent OwnerAddress
AMBRX INC10975 NORTH TORREY PINES ROAD LA JOLLA CA 92037

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liu, Junjie San Diego, US 117 1564
Miao, Zhenwei San Diego, US 81 2181
Norman, Thea San Diego, US 56 1913

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