Chimeric receptors with 4-1BB stimulatory signaling domain
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United States of America Patent
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Mar 19, 2013
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Jul 12, 2012
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Nov 5, 2003
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Abstract
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.
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