Locally targeted anti-fibrotic agents and methods of use
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United States of America Patent
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Mar 26, 2013
Grant Date -
Apr 26, 2012
app pub date -
Oct 26, 2010
filing date -
Oct 26, 2010
priority date (Note) -
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Abstract
Effective devices and methods using an antifibrotic agent are provided for treating fibrosis or treating normal fibrous tissue. The devices and methods comprise an antifibrotic agent to degrade shrink, relax or stretch at least a portion of the fibrotic tissue. In some embodiments, the methods and devices are configured to immediately release an effective amount of the antifibrotic agent within 24 hours. In some embodiments, when the device comes in contact directly or indirectly with an activator, the antifibrotic agent will be immediately released from the depot. In some embodiments, the depot provides sustained release of the antifibrotic agent over a period of up to one year to treat fibrous tissue.
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