Glycopegylated factor IX
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United States of America Patent
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Mar 26, 2013
Grant Date -
Apr 1, 2010
app pub date -
Oct 23, 2009
filing date -
May 25, 2005
priority date (Note) -
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Abstract
Conjugates between Factor IX and PEG moieties are disclosed in the present application. The conjugates are linked via a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. Conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
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