Substituted heterocyclic mercaptosulfonamide metalloprotease inhibitors
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United States of America Patent
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Mar 26, 2013
Grant Date -
Jun 16, 2011
app pub date -
Sep 2, 2009
filing date -
Sep 3, 2008
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Abstract
The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These compounds are designed to be potent selective inhibitors of matrix metalloproteinases (MMPs), including, for example, gelatinases, collagenases, matrilysins, metalloelastase, stromelysin, and membrane-type 1 matrix metalloproteinase. These inhibitors may be used for the control of physiological and pathological processes and disease conditions in which MMPs are believed to play significant functions.
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