Targeted deletion of cellular DNA sequences
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United States of America Patent
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Apr 2, 2013
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app pub date -
Dec 15, 2005
filing date -
Aug 8, 2003
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Abstract
Disclosed herein are methods and compositions for targeted deletion of double-stranded DNA. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins, or polynucleotides encoding same, into a cell such that two targeted cleavage events occur. Subsequent cellular repair mechanisms result in deletion of sequences between the two cleavage sites.
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