Devices and methods for coupling mass spectrometry devices with chromatography systems
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United States of America Patent
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Apr 2, 2013
Grant Date -
Sep 23, 2010
app pub date -
Nov 3, 2008
filing date -
Nov 2, 2007
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Abstract
One embodiment of the invention provides a method of preparing an eluted sample containing salts or buffers from a liquid chromatography device for analysis by a mass spectrometry device. The method includes: continuously providing a non-polar solvent to the mass spectrometry device; receiving the eluted sample from the liquid chromatography device; flowing the eluted sample over a solid phase extraction column; flowing the non-polar solvent over the solid phase extraction column; and presenting non-polar solvent and the eluted sample to the mass spectrometry device.
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