Methods of measuring ADAMTS13-mediated in vivo cleavage of von Willebrand factor and uses thereof
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United States of America Patent
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Apr 9, 2013
Grant Date -
Jun 10, 2010
app pub date -
Dec 3, 2009
filing date -
Dec 5, 2008
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Abstract
The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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