Reducing myocardial reperfusion injury by the combination therapy of protein kinase A activation and B1-adrenergic receptor blockade
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United States of America Patent
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Apr 9, 2013
Grant Date -
Aug 4, 2011
app pub date -
Jun 12, 2009
filing date -
Jun 12, 2008
priority date (Note) -
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Abstract
Embodiments of the invention are directed to methods of treating reperfusion or resuscitation injury in an individual in need of such treatment, comprising the step of administering to the individual who has had, having, or is at immediate risk of having an ischemic event an amount of a composition comprising a protein kinase A (PKA) activator and a β1-adrenergic receptor antagonist sufficient to reduce reperfusion injury to an ischemic tissue.
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