Compounds and their use as BACE inhibitors

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United States of America Patent

PATENT NO 8415483
APP PUB NO 20120165347A1
SERIAL NO

13331284

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.

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Patent Owner(s)

Patent OwnerAddress
ASTRAZENECA AB151 85 SÖDERTÄLJE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Öhberg, Liselotte Södertälje, SE 4 17
Csjernyik, Gabor Södertälje, SE 7 52
Karlström, Sofia Södertälje, SE 6 23
Kers, Annika Södertälje, SE 35 242
Kolmodin, Karin Södertälje, SE 24 223
Nylöf, Martin Södertälje, SE 5 14
Rakos, Laszlo Södertälje, SE 22 200
Söderman, Peter Södertälje, SE 6 24
Sandberg, Lars Södertälje, SE 45 615
Sehgelmeble, Fernando Södertälje, SE 14 154
Swahn, Britt-Marie Södertälje, SE 25 141
Von, Berg Stefan Södertälje, SE 23 114

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