Compositions that include hemagglutinin
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United States of America Patent
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Apr 16, 2013
Grant Date -
Nov 1, 2007
app pub date -
Mar 6, 2007
filing date -
Mar 7, 2006
priority date (Note) -
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Abstract
Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions can further include a Toll-like Receptor agonist and a carrier protein.
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