Drug delivery vehicles, methods of manufacture, and methods of use thereof
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United States of America Patent
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Apr 16, 2013
Grant Date -
Aug 18, 2011
app pub date -
Jul 28, 2010
filing date -
Jul 29, 2009
priority date (Note) -
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Abstract
Drug delivery vehicles that release one or more drugs, e.g., an opioid antagonist and/or an opioid, in response to changes in the chemistry of body fluids, specifically in response to changes in the partial pressure of CO2 in the environment of the hydrogel are described. The drug delivery vehicles include hydrogels that swell or shrink in response to changes in the partial pressure of CO2 in their environment, thus regulating release of an entrapped drug.
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