11βhydroxysteroid dehydrogenase type 1
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United States of America Patent
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Apr 16, 2013
Grant Date -
Aug 19, 2010
app pub date -
Oct 8, 2008
filing date -
Oct 8, 2007
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Abstract
The invention provides gene-targeted non-human animals comprising a genetically modified 11βHSD1 gene encodes a mutant 11βHSD1 polypeptide which is modulated by human 11βHSD1 modulating compounds. The invention further provides cells expressing mutant 11βHSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11βHSD1. The invention further provides methods of identifying agents that modulate 11βHSD1 activity, and are useful to treat 11βHSD1-related metabolic disorders.
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