Tetrahydroisoquinolines and intermediates therefor
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United States of America Patent
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Apr 16, 2013
Grant Date -
Mar 31, 2011
app pub date -
Jun 4, 2009
filing date -
Jun 4, 2008
priority date (Note) -
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Abstract
Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. One such intermediate has the following structure:
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