Alpha 1-3 N-galactosyltransferase with altered donor specificities
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United States of America Patent
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Apr 23, 2013
Grant Date -
Sep 8, 2011
app pub date -
Aug 22, 2007
filing date -
Aug 22, 2007
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Abstract
The invention generally features compositions and methods based on the structure-based design of alpha 1-3 N-Acetylgalactosaminyltransferase (alpha 3 GaINAc-T) enzymes from alpha 1-3 galactosyltransferase (a3Gal-T) that can transfer 2′-modified galactose from the corresponding UDP-derivatives due to substitutions that broaden the alpha 3Gal-T donor specificity and make the enzyme a3 GaINAc-T.
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