Two-step temperature profile for the propagation of viruses
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United States of America Patent
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Apr 23, 2013
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app pub date -
Apr 30, 2008
filing date -
May 4, 2007
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Abstract
The present invention provides a method for the production of a virus. The method includes providing a host cell that has been infected by the virus and cultivating the infected host cell at two different temperatures. The virus produced by the cultivation steps is subsequently collected. By using the dual temperature cultivation process, high titer and improved purity can be obtained.
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