Method of producing FR901228
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Apr 23, 2013
Grant Date -
Sep 6, 2012
app pub date -
May 17, 2012
filing date -
Sep 1, 2000
priority date (Note) -
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Abstract
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.
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