Bis-platinum complexes with antitumor activity
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United States of America Patent
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Apr 23, 2013
Grant Date -
Nov 18, 2010
app pub date -
Dec 21, 2006
filing date -
Dec 22, 2005
priority date (Note) -
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Abstract
A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of —B—, —B—(CH2)r—B—, —B—(CH2)r—B—(CH2)z—B—, wherein r and z are an integer from 2 to 8, B is a —NR1— or —N(R2)2+1/pQ−p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q−p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO− wherein R3 has the same meanings as R, independently from one another and R4—O—SO3− wherein R4 is (C2-C14)alkyl with the proviso that, when Q−p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.
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