Specifically targeted catalytic antagonists and uses thereof
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United States of America Patent
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Apr 30, 2013
Grant Date -
Oct 27, 2011
app pub date -
Nov 23, 2010
filing date -
Apr 28, 1999
priority date (Note) -
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Abstract
This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.
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