Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
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United States of America Patent
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Apr 30, 2013
Grant Date -
Jul 2, 2009
app pub date -
Feb 24, 2007
filing date -
Feb 24, 2006
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Abstract
Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.
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