Method to restore cartilaginous phenotype of chondrocytes after cultured and expanded in vitro
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United States of America Patent
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Apr 30, 2013
Grant Date -
Sep 8, 2011
app pub date -
Mar 2, 2010
filing date -
Mar 2, 2010
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Abstract
The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes.
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