Bi-dentate compounds as kinase inhibitors
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United States of America Patent
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Apr 30, 2013
Grant Date -
Jul 14, 2011
app pub date -
Dec 16, 2010
filing date -
Jul 31, 2007
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Abstract
The present disclosure provides compound having the general structure A or pharmaceutically acceptable salts thereof:
wherein Het is an aromatic moiety comprising a heterocyclic structure mimicking ATP, P is a docking site derived peptide or a docking site peptide mimetic, and L is a linking moiety, wherein L links the ATP mimetic to the docking site peptide moiety. The compounds having the general structure A can serve as inhibitors of kinases, such as the kinases JNK, Erk and p38.
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