T cell receptors and related materials and methods of use

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8431690
APP PUB NO 20110104129A1
SERIAL NO

12870941

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Abstract

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The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for a cancer antigen, e.g., a renal cell carcinoma antigen, wherein the TCR recognizes the cancer antigen in a major histocompatibility complex (MHC)-independent manner. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host using the inventive TCRs or related materials.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESBETHESDA MD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hanada, Kenichi Bethesda, US 14 122
Wang, Qiong J Reston, US 11 55
Yang, James C Silver Spring, US 16 56

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