Apparatus and method for modulating neurochemical levels in the brain

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United States of America Patent

PATENT NO 8433415
APP PUB NO 20120209347A1
SERIAL NO

13449559

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Abstract

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A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system uses a chemosensor implanted in the striatum instead of the GPi. An alternative system for treating benign essential tremor uses a stimulus electrode implanted in the thalamus with feedback taken from a chemosensor in the striatum.

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Patent Owner(s)

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THE TRUSTEES OF DARTMOUTH COLLEGE11 ROPE FERRY ROAD ROOM 6210 HANOVER NH 03755

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chemov, Mykyta M Lebanon, US 1 9
Leiter, James C Woodstock, US 3 34
Roberts, David W Lyme, US 70 1501

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