Chimeric ligand-gated ion channels and methods of use thereof
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United States of America Patent
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May 7, 2013
Grant Date -
May 27, 2010
app pub date -
Oct 9, 2009
filing date -
Oct 9, 2008
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Abstract
The present invention provides novel chimeric receptors that have unique pharmacology. In particular, the chimeric receptors comprise a mutated ligand binding domain of the α7 nicotinic acetylcholine receptor fused to a transmembrane or channel domain from a ligand-gated ion channel protein. The mutations in the ligand binding domain confer selective binding of compounds. Methods of using the novel chimeric receptors of the invention as well as compounds that preferentially bind and activate the chimeric receptors are also disclosed.
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