Endothelial nitric oxide synthase antagonists and uses thereof for inhibiting oxygen toxicity
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United States of America Patent
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May 7, 2013
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app pub date -
May 9, 2011
filing date -
May 10, 2010
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Abstract
Compositions and methods for inhibiting the interaction between eNOS and β-actin are provided for use in inhibiting or reducing lung injury from oxygen toxicity. One embodiment provides a synthetic or recombinant polypeptide having the β-actin binding domain of eNOS, wherein the polypeptide inhibits or reduces eNOS activity in lung endothelial cells.
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