Method for the separation of S-(−)-amlodipine from racemic amlodipine

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United States of America Patent

PATENT NO 8436188
APP PUB NO 20100069445A1
SERIAL NO

12447306

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Abstract

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Disclosed is a method for the separation of S-(−)-amlodipine from a racemic amlodipine. Featuring the use of inexpensive L-tartaric acid as an optical resolution agent and DMAC as a solvent, the separation method allows the resolution of S-(−)-amlodipine from racemic amlodipine at high yield and to a satisfactory enantiomeric excess and thus is economically favorable and applicable to the mass production of the optical isomer.

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Patent Owner(s)

Patent OwnerAddress
CJ CHEILJEDANG CORPORATIONSEOUL 100-400

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cho, Il Hwan Seoul, KR 33 84
Lim, Dong Kwon Gyeonggi-do, KR 16 27
Song, Seog Beom Gyeonggi-do, KR 6 0
Youn, Yong Sik Gyeonggi-do, KR 19 23

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