Stabilized bioactive peptides and methods of identification, synthesis, and use
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United States of America Patent
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May 14, 2013
Grant Date -
Mar 8, 2012
app pub date -
Aug 31, 2011
filing date -
Oct 13, 1998
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Abstract
An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.
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