Methods of purifying anti A β antibodies

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United States of America Patent

PATENT NO 8440799
APP PUB NO 20110160437A1
SERIAL NO

12903053

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Abstract

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The present application provides methods of purifying Aβ binding proteins having a Fc region, for example, anti-Aβ antibodies or antibody fusions, by adsorbing the Aβ binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed Aβ binding protein. The present application also features methods of eluting the purified Aβ binding protein as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.

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Patent Owner(s)

  • JANSSEN ALZHEIMER IMMUNOTHERAPY;WYETH LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Godavarti, Ranganathan Burlington, US 8 357
Iskra, Timothy Derry, US 5 132

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