Use on minicircle vectors for cardiac gene therapy

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United States of America Patent

PATENT NO 8445454
APP PUB NO 20110118333A1
SERIAL NO

12925483

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Abstract

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Compositions and methods are provided for the treatment of an ischemic cardiovascular condition by providing a patient with a novel non-viral minicircle DNA vector comprising polynucleotide sequences that potentiate HIF-1 activity, including RNAi or antisense agents selective for proteins involved in HIF1 inactivation.

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Patent Owner(s)

Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYBUILDING 170 THIRD FLOOR MAIN QUAD P O BOX 20386 STANFORD CA 94305-2038

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Zhi-Ying Foster City, US 16 172
Huang, Mei Menlo Park, US 30 122
Kay, Mark A Los Altos, US 80 1291
Wu, Joseph Palo Alto, US 32 301

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