Process for the preparation of optically active N-benzyl-3 hydroxypyrrolidines
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United States of America Patent
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May 21, 2013
Grant Date -
Apr 26, 2012
app pub date -
Nov 24, 2009
filing date -
Nov 24, 2008
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Abstract
The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)—N-benzyl-3-hydroxypyrrolidine and (R)—N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)—N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.
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