Cell transdifferentiation into brown adipocytes
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United States of America Patent
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Jun 4, 2013
Grant Date -
Mar 10, 2011
app pub date -
Aug 30, 2010
filing date -
Aug 28, 2009
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Abstract
A method for converting animal cells into brown adipose tissue cells is provided that includes transforming the animal cells using an expression vector. The expression vector includes a nucleotide sequence encoding HB-EGF operatively linked to a promoter and a nucleotide sequence encoding ADAM 12 operatively linked to a promoter. Converting animal cells to brown adipose tissue cells can be used to treat obesity or to treat cancer by converting target cells to brown adipose tissue cells.
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