Process for solubilizing glucagon-like peptide 1 compounds

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United States of America Patent

PATENT NO 8455433
APP PUB NO 20130072658A1
SERIAL NO

13571443

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Abstract

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Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.

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Patent Owner(s)

Patent OwnerAddress
ELI LILLY AND COMPANYLILLY CORPORATE CENTER INDIANAPOLIS INDIANA 46285 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Prouty,, Jr Walter Francis Indianapolis, US 4 47
Rinella,, Jr Joseph Vincent Collegeville, US 4 47

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