Method of treating cancer and/or cellular proliferative conditions and agents targeting hyaluronan anabolism useful for same
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United States of America Patent
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Jun 11, 2013
Grant Date -
Jan 12, 2012
app pub date -
Jun 13, 2011
filing date -
Oct 10, 2003
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Abstract
The present invention relates generally to the modulation of hyaluronan (HA) synthesis and degradation. The present invention further contemplates modulation of cellular proliferation, useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis. The present invention is directed to compounds, agents, pharmaceutically active agents, medicaments, therapeutics, actives, drugs and the like which specifically target a portion of HAS which is accessible to the extracellular environment in malignant or inflammatory or proliferative cells but which portion is not accessible to the external environment in “normal” cells. A “normal” cell in this instance is a non-malignant, inflammatory or proliferative cell.
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