Chemical linkers and cleavable substrates and conjugates thereof

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United States of America Patent

PATENT NO 8461117
APP PUB NO 20100145036A1
SERIAL NO

12521391

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Abstract

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The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

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Patent Owner(s)

  • E. R. SQUIBB & SONS, L.L.C.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Liang Discovery Bay, US 848 7999
Gangwar, Sanjeev Foster City, US 90 1684
Guerlavais, Vincent Arlington, US 43 1529
Passmore, David B San Carlos, US 27 1283
Sufi, Bilal Santa Clara, US 9 675
Zhang, Qian Danville, US 798 6785

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