Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease
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United States of America Patent
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Jun 18, 2013
Grant Date -
Sep 29, 2011
app pub date -
Mar 28, 2011
filing date -
Oct 8, 2008
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Abstract
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
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