Nucleic acid encoding a zinc finger that recognizes the sodium channel Nav 1.8 (PN3) gene

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United States of America Patent

PATENT NO 8466267
APP PUB NO 20090069259A1
SERIAL NO

11825655

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Abstract

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A variety of zinc finger proteins (ZFPs) and methods utilizing such proteins are provided for use in treating neuropathic pain. ZFPs that bind to a target site in genes that are aberrantly expressed in subjects having neuropathic pain are described. In addition, ZFPs that bind to a target site in genes expressed at normal levels in subjects experiencing neuropathic pain, modulation of whose expression results in decreased pain perception, are also provided. For example, genes that are over-expressed in the dorsal root ganglia (DRG) of pain patients (e.g., VR1, TRKA and/or Nav1.8) can be repressed, whereas genes that are under-expressed in the same populations can be activated.

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Patent Owner(s)

  • SANGAMO BIOSCIENCES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Collingwood, Trevor Novato, US 27 889

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