Neuroprotective compositions and methods
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United States of America Patent
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Jun 18, 2013
Grant Date -
Nov 22, 2012
app pub date -
Sep 19, 2011
filing date -
Oct 10, 2006
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Abstract
Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keap1, a negative regulator of the transcription factor Nrf2, and prevent Keap1-mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keap1/Nrf2 complex.
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