Substrates and internal standards for mass spectrometry detection

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United States of America Patent

PATENT NO 8476414
APP PUB NO 20090068634A1
SERIAL NO

12210262

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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An inventive substrate is provided which includes a substrate compound of formula A—B1—B2—B3: wherein A is a sugar moiety; B1 is a linker moiety allowing the conjugation of moiety A and the remaining structure of the substrate; B2 contains a permanently charged element such as a quaternary ammonium group so as to increase proton affinities and ionization efficiencies for mass spectrometry detection efficiencies analysis; and B3 of various carbon length conferring specificities to targeted enzymes. Also provided is a process to detect lysosomal diseases by contacting a sample with the inventive substrate along with an internal standard which is isotope-labeled analog of the product cleaved by a targeted enzyme upon the substrate.

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Patent Owner(s)

  • PERKINELMER HEALTH SCIENCES, INC.;PERKINELMER LAS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cerda, Blas Milford, US 21 121

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