Synthesis of epothilones, intermediates thereto, analogues and uses thereof

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United States of America Patent

PATENT NO 8481575
SERIAL NO

13040211

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Abstract

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The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

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Patent Owner(s)

  • SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Balog, Aaron Lambertville, US 22 331
Bertinato, Peter Old Lyme, US 37 490
Chou, Ting-Chao Paramus, US 51 420
Danishefsky, Samuel J Englewood, US 112 1050
Kamenecka, Ted San Diego, US 22 331
Meng, Dongfang Westfield, US 31 189
Savin, Kenneth A Indianapolis, US 23 336
Sorensen, Erik J Princeton, US 25 383
Su, Dai-shi Dresher, US 43 409

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