Instruments and methods for mixing the contents of a detection chamber

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United States of America Patent

PATENT NO 8491178
SERIAL NO

13414195

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Importance

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Abstract

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A receptacle having interconnected chambers arranged to permit multiple process steps to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample. The detector can be used to detect an optical signal emitted by the contents of the receptacle.

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Patent Owner(s)

  • GEN-PROBE INCORPORATED;QUALIGEN, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Breidenthal, Scott S Oceanside, US 14 532
Fan, Sara H San Diego, US 10 499
Lee, Richard S San Diego, US 23 599
Nelson, Norman C San Diego, US 76 2169
Scott, Matthew J Oceanside, US 15 532
Taylor, Jason A Windham, US 17 1331

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