Antibacterial peptides active in systemic infections

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United States of America Patent

PATENT NO 8492515
APP PUB NO 20100323951A1
SERIAL NO

12866864

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Abstract

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Antimicrobial peptides of the formula are provided: X1—X2—PrO—X3—X4—PrO-Arg-Pro-Tyr-Leu-Pro-X5-Pro-Arg-Pro-Pro-Arg-Pro-Y, wherein X1 is a natural or non-natural amino acid having a free amino group or 1-amino-cyclohexyl carboxylic acid, X2 is Arg or N-methyl-Arg, X3 is Asp or GIu, X4 is Arg or Lys, X5 is Arg or Lys, and Y is Arg, Arg-NH2, N-methyl-Arg, N-methyl-Arg-NH2, Val-Arg, Val-Arg-NH2, Val-(N-methyl-Arg), or Val-(N-methyl)-Arg-NH2, and salts thereof.

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Patent Owner(s)

  • TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Otvos, Laszlo Audubon, US 14 29

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