Recombinant protein S composition

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United States of America Patent

PATENT NO 8501914
APP PUB NO 20100162418A1
SERIAL NO

12540501

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Abstract

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A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as “RAGE”) than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.

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Patent Owner(s)

Patent OwnerAddress
KYOWA HAKKO KIRIN CO LTDTOKYO 100-8185

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kanda, Yutaka Tokyo, JP 81 2854
Kato, Akifumi Tokyo, JP 25 269
Sato, Hiroshi Tokyo, JP 974 10580
Satoh, Mitsuo Tokyo, JP 52 2487
Yamada, Tsuyoshi Tokyo, JP 73 444

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