Hybridization chain reaction amplification for in situ imaging
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United States of America Patent
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Aug 13, 2013
Grant Date -
Jul 26, 2012
app pub date -
Jan 31, 2012
filing date -
Mar 8, 2005
priority date (Note) -
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Abstract
The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that comprises a target region able to specifically bind an analyte of interest and an initiator region that is able to initiate polymerization of nucleic acid monomers. After contacting a sample with the probe, labeled monomers are provided that form a tethered polymer. Triggered probes and self-quenching monomers can be used to provide active background suppression.
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