antibody fragments
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United States of America Patent
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Aug 20, 2013
Grant Date -
Mar 15, 2012
app pub date -
Nov 17, 2011
filing date -
Feb 28, 2001
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention is directed to a pharmaceutical composition comprising F(ab′)2 antibody fragments that are preferably free from albumin and of whole antibodies and also substantially free of pyrogens, and an effective amount of a pharmaceutically acceptable carrier. It is also directed to a method for the production of a pharmaceutical composition comprising F(ab′)2 antibody fragments using scrum or blood plasma of a mammal that has been previously immunized as a source of antibodies. The serum or blood plasma is digested with an enzyme pepsin, followed by separation and purification until the pharmaceutical composition of F(ab′)2 fragments is free of albumin and complete antibodies, and substantially free of pyrogens.
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