Netrin-1 compositions and methods of use thereof
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United States of America Patent
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Sep 3, 2013
Grant Date -
Oct 14, 2010
app pub date -
Nov 3, 2008
filing date -
Nov 2, 2007
priority date (Note) -
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Abstract
Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to inhibit or reduce fusion of male gametes with female gametes in a female subject Still another embodiment provides a method for diagnosing male infertility by determining the amount of netrin-1 in a sample of epididymal fluid or semen from a male subject, comparing the amount of netting-1 in the sample to levels of netrin-1 in samples of epididymal fluid or semen from fertile males, wherein levels of netrin-1 in the sample from the male subject that are higher or lower than levels of netrin-1 in samples from fertile males are indicative of male infertility in the male subject.
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