Targeted delivery to human diseases and disorders
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United States of America Patent
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Sep 10, 2013
Grant Date -
Nov 8, 2012
app pub date -
May 9, 2012
filing date -
May 22, 2008
priority date (Note) -
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Abstract
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.
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